LITERATUR REVIEW PENGARUH PEMBERIAN MULTI MODAL ANALGESIA INTRA ANESTESI TERHADAP STABILITAS TEKNANAN DARAH PASIEN SELAMA OPERASI
DOI:
https://doi.org/10.71282/jurmie.v2i12.1376Keywords:
Hemodynamics, Intra-Anesthesia, Multimodal Analgesia, SurgeryAbstract
Blood pressure stability during surgery is crucial to prevent anesthetic complications. Blood pressure fluctuations often occur due to pain response and surgical stress. One effective way to control this condition is through intra-anesthetic multimodal analgesia, which involves the use of a combination of analgesic drugs with different mechanisms of action. Research by (Wang et al. 2025), (Negm et al. 2025) (Besnier et al. 2024) shows that a combination of drugs such as dexmedetomidine, lidocaine, and magnesium sulfate can maintain hemodynamic stability and reduce the need for inhalation anesthesia. Therefore, it is important to review the scientific evidence regarding the effect of multimodal intra-anesthetic analgesia on blood pressure stability in patients during surgery. Objective: This literature review aims to determine and analyze the effect of multimodal intra-anesthetic analgesia on blood pressure stability in patients during surgery, based on the results of relevant national and international studies in the last five years (2023–2025). Research Method: This study design uses a literature review method, examining and analyzing 10 scientific journals focusing on the topic of multimodal intra-anesthetic analgesia. The journals used consist of six national journals and four international journals from reliable sources such as the Indonesian Journal of Anesthesiology Nursing and BMC Anesthesiology. The analysis was conducted by reviewing the research design, interventions used, blood pressure parameters, and intraoperative hemodynamic stability results. Research Results: The results of the review show that multimodal intra-anesthetic analgesia is effective in maintaining blood pressure stability during surgery. The combination of drugs such as dexmedetomidine, lidocaine, paracetamol, low-dose ketamine, and magnesium sulfate was able to reduce blood pressure fluctuations and the need for inhalation anesthesia compared to the use of opioids alone. All journals reviewed showed consistent results supporting the positive effects of this approach on patient hemodynamic stability.
Downloads
References
Besnier, Emmanuel, Mouhamed Djahoum Moussa, Caroline Thill, Florian Vallin, Nathalie Donnadieu, Sophie Ruault, Emmanuel Lorne, et al. 2024. “Free Anaesthesia with Dexmedetomidine and Lidocaine versus Based Anaesthesia in Cardiac Surgery : Study Protocol of a French Randomised , Multicentre and Blinded OFACS Trial.” BMJ Open, 1–7. https://doi.org/10.1136/bmjopen-2023-079984.
Bumi, Devina Martina, Tjahya Aryasa Em, and Made Wiryana. 2015. “Penggunaan Opioid Free Anesthesia Pada Pasien Kehamilan Ektopik Terganggu Dengan Hemodinamik Stabil Yang Menjalani Operasi Laparotomi Opioid Free Anesthesia in Ectopic Pregnancy Patient with Stable Hemodynamics Undergoing Laparotomy Procedure.” Jurnal Anestesi Obstetri Indonesia Selain 6 (2023): 94–100.
Hilton. 2024. “PRODUCT REVIEW / ÉVALUATION DE PRODUIT.” JBI Critical Appraisal Checklist for Systematic Reviews and Research Syntheses URL:, 180–83. https://doi.org/10.29173/jchla29801.
Negm, Essamedin M, Mohammed A Younus, Ahmed A Morsy, Sahar M S El Gammal, Mona A El-harrisi, Fayrouz A Abdel Sameaa, Rawan A M Rashad, Tamer S Elserafy, and Ahmed M Gouda. 2025. “Opioid-Sparing Multimodal Analgesia for Post- Craniotomy Pain : A Randomized , Double-Blind , Placebo-Controlled Trial.” BMC Anestesiology. https://doi.org/10.1186/s12871-025-03306-5.
Nugroho, D., & Pratama, R. 2024. “Pengaruh Kombinasi Paracetamol Dan Magnesium Sulfat Terhadap Stabilitas Tekanan Darah Pada Pasien Bedah Ortopedi Dengan Anestesi.” Jurnal Keperawatan Dan Anestesiologi Indonesia, 9(2), 110–118. 42 (2): 164–71. https://doi.org/10.55497/majanestcricar.v42i2.318.
Pamudji, Ivan Sebastian, Tjahya Aryasa, Cynthia Dewi Sinardja, and IGAG Utara Hartawan. 2025. “Anestesi Bebas Opioid Untuk Total Abdominal Histerektomi Dengan Bisalfingoovorektomi: Optimalisasi Manajemen Nyeri Dan Stabilitas Hemodinamik.” COMSERVA : Jurnal Penelitian Dan Pengabdian Masyarakat 5 (1): 386–94. https://doi.org/10.59141/comserva.v5i1.3336.
Salem, Ahmed E., Mohamed G. El-Mawy, and Adel F. Al-Kholy. 2022. “Multimodal, Non-Opioid Based Analgesia for Women Presented for Laparoscopic Hysterectomy.” Egyptian Journal of Anaesthesia 38 (1): 139–49. https://doi.org/10.1080/11101849.2022.2031547.
Shi, Ke, and Kai Mao. 2024. “Best Practices in Intraoperative Pain Management: Exploring Multimodal Analgesia Strategies.” MEDS Clinical Medicine 5 (2): 8–15. https://doi.org/10.23977/medsc.2024.050202.
Wang, Lei, Xinhua Hong, Yiting Xue, and Zhen Su. 2025. “Effect of Opioid Sparing Strategies on Postoperative Pain and Perioperative Hemodynamics in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Study.” BMC Anesthesiology 25 (1). https://doi.org/10.1186/s12871-025-02953-y.
Wibowo, Anthony Hadi, Wahyudi, Andi Salahuddin, Hisbullah, Faisal, and Muh Rum. 2023. “Pengaruh Blok Pleksus Servikal Superfisialis Menggunakan Levobupivakain Isobarik 0,25% Terhadap Hemodinamik, Kebutuhan Obat Anestesi, Dan Intensitas Nyeri Pada Pembedahan Regio Klavikula.” Majalah Anestesia & Critical Care 41 (2): 69–81. https://doi.org/10.55497/majanestcricar.v41i2.279.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Fahria Nur Maulida, Miftahul Khoeriyah, Nidaul Khaira (Author)
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
