PENGARUH PEMBERIAN MULTI MODAL ANALGESIA INTRA ANESTESI TERHADAP STABILITAS TEKNANAN DARAH PASIEN SELAMA OPERASI
DOI:
https://doi.org/10.71282/jurmie.v2i12.1486Keywords:
Hemodynamics, Intra-Anesthesia, Multimodal Analgesia, SurgeryAbstract
Background: Blood pressure stability during surgery is essential to prevent anesthetic complications caused by pain and surgical stress. Multimodal intra-anesthetic analgesia, which combines analgesic drugs with different mechanisms of action, has been shown to help maintain hemodynamic stability. Several studies report that combinations of dexmedetomidine, lidocaine, ketamine, paracetamol, and magnesium sulfate can reduce blood pressure fluctuations and inhalation anesthetic requirements. Objective: This literature review aims to analyze the effect of multimodal intra-anesthetic analgesia on blood pressure stability in surgical patients based on studies published between 2023 and 2025. Methods: A literature review was conducted using 10 scientific journals (six national and four international) from credible sources. The analysis focused on study design, analgesic interventions, blood pressure parameters, and intraoperative hemodynamic outcomes. Results: The review demonstrates that multimodal intra-anesthetic analgesia effectively maintains intraoperative blood pressure stability. Compared with opioid-based analgesia alone, multimodal approaches consistently reduced blood pressure fluctuations and anesthetic requirements.
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References
Besnier, Emmanuel, Mouhamed Djahoum Moussa, Caroline Thill, Florian Vallin, Nathalie Donnadieu, Sophie Ruault, Emmanuel Lorne, et al. 2024. “Free Anaesthesia with Dexmedetomidine and Lidocaine versus Based Anaesthesia in Cardiac Surgery : Study Protocol of a French Randomised , Multicentre and Blinded OFACS Trial.” BMJ Open, 1–7. https://doi.org/10.1136/bmjopen-2023-079984.
Bumi, Devina Martina, Tjahya Aryasa Em, and Made Wiryana. 2015. “Penggunaan Opioid Free Anesthesia Pada Pasien Kehamilan Ektopik Terganggu Dengan Hemodinamik Stabil Yang Menjalani Operasi Laparotomi Opioid Free Anesthesia in Ectopic Pregnancy Patient with Stable Hemodynamics Undergoing Laparotomy Procedure.” Jurnal Anestesi Obstetri Indonesia Selain 6 (2023): 94–100.
Hilton. 2024. “PRODUCT REVIEW / ÉVALUATION DE PRODUIT.” JBI Critical Appraisal Checklist for Systematic Reviews and Research Syntheses URL:, 180–83. https://doi.org/10.29173/jchla29801.
Negm, Essamedin M, Mohammed A Younus, Ahmed A Morsy, Sahar M S El Gammal, Mona A El-harrisi, Fayrouz A Abdel Sameaa, Rawan A M Rashad, Tamer S Elserafy, and Ahmed M Gouda. 2025. “Opioid-Sparing Multimodal Analgesia for Post- Craniotomy Pain : A Randomized , Double-Blind , Placebo-Controlled Trial.” BMC Anestesiology. https://doi.org/10.1186/s12871-025-03306-5.
Pamudji, Ivan Sebastian, Tjahya Aryasa, Cynthia Dewi Sinardja, and IGAG Utara Hartawan. 2025. “Anestesi Bebas Opioid Untuk Total Abdominal Histerektomi Dengan Bisalfingoovorektomi: Optimalisasi Manajemen Nyeri Dan Stabilitas Hemodinamik.” COMSERVA : Jurnal Penelitian Dan Pengabdian Masyarakat 5 (1): 386–94. https://doi.org/10.59141/comserva.v5i1.3336.
Prameita Rahmawati, Ian Tirta, Marilaeta Cindryani Ra Ratumasa. 2024. “Erector Spinae Plane Block Menunjang Stabilitas Hemodinamik Dan Analgesia Pada Video-Assisted Thoracoscopy Surgery: Sebuah Laporan Kasus Prameita.” Majalah Anestesia & Critical Care 42 (2): 164–71. https://doi.org/10.55497/majanestcricar.v42i2.318.
Salem, Ahmed E., Mohamed G. El-Mawy, and Adel F. Al-Kholy. 2022. “Multimodal, Non-Opioid Based Analgesia for Women Presented for Laparoscopic Hysterectomy.” Egyptian Journal of Anaesthesia 38 (1): 139–49. https://doi.org/10.1080/11101849.2022.2031547.
Shi, Ke, and Kai Mao. 2024. “Best Practices in Intraoperative Pain Management: Exploring Multimodal Analgesia Strategies.” MEDS Clinical Medicine 5 (2): 8–15. https://doi.org/10.23977/medsc.2024.050202.
Wang, Lei, Xinhua Hong, Yiting Xue, and Zhen Su. 2025. “Effect of Opioid Sparing Strategies on Postoperative Pain and Perioperative Hemodynamics in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Study.” BMC Anesthesiology 25 (1). https://doi.org/10.1186/s12871-025-02953-y.
Wibowo, Anthony Hadi, Wahyudi, Andi Salahuddin, Hisbullah, Faisal, and Muh Rum. 2023. “Pengaruh Blok Pleksus Servikal Superfisialis Menggunakan Levobupivakain Isobarik 0,25% Terhadap Hemodinamik, Kebutuhan Obat Anestesi, Dan Intensitas Nyeri Pada Pembedahan Regio Klavikula.” Majalah Anestesia & Critical Care 41 (2): 69–81. https://doi.org/10.55497/majanestcricar.v41i2.279.
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