PENGARUH OBAT BUPIVACAIN TERHADAP MAP DAN FREKUENSI NADI PADA ANESTESI SPINAL DI RS PKU MUHAMMADIYAH GOMBONG
DOI:
https://doi.org/10.71282/jurmie.v3i8.2518Keywords:
spinal anesthesia, bupivacaine, mean arterial pressure, heart rate, hemodynamics.Abstract
Background: Hemodynamic changes are common during spinal anesthesia, particularly following the administration of bupivacaine, which may affect mean arterial pressure (MAP) and heart rate. Monitoring these parameters is essential to maintain hemodynamic stability throughout surgical procedures. Objective: This study aimed to determine the effect of bupivacaine administration on mean arterial pressure (MAP) and heart rate in patients undergoing spinal anesthesia at PKU Muhammadiyah Gombong Hospital. Methods: This quantitative study employed a pre-experimental one-group pretest-posttest design. A total of 181 respondents were recruited using accidental sampling. Mean arterial pressure and heart rate were measured 5 minutes before and 5 minutes after the administration of spinal anesthesia. Data were analyzed using the Wilcoxon Signed-Rank Test. Results: A significant change in mean arterial pressure was observed following bupivacaine administration (p < 0.001). In contrast, no significant change was found in heart rate (p = 0.823). Conclusion: Bupivacaine administration significantly affected mean arterial pressure but did not significantly influence heart rate in patients undergoing spinal anesthesia.
Downloads
References
Abebe MM, Arefayne NR, Temesgen MM, Admass BA. Incidence and predictive factors associated with hemodynamic instability among adult surgical patients in the post-anesthesia care unit, 2021: A prospective follow up study. Ann Med Surg. 2022;74:103321.
Besha A, Zemedkun A, Tadesse M, et al. Effects of hyperbaric and isobaric bupivacaine on hemodynamic profiles and block characteristics among parturients undergoing elective cesarean section under spinal anesthesia: a randomized controlled trial. J Pain Res. 2023;16:3545-3558.
Budi T, Untari I, Rizky M. Perubahan tekanan darah intra anestesi pada pasien dengan spinal anestesi. Quantum Wellness J Ilmu Kesehat. 2024;1(4):251-257.
Disli Z, Gundogdu H, Delen L. Effects of different bupivacaine injection speeds on hemodynamic and some other parameters during spinal anesthesia for cesarean section. Medicine Science. 2025;14(3):910.
Etania C, Hanafie A, Lubis AP. Prophylactic effectiveness of phenylephrine 100 mcg and ephedrine 10 mg on the incidence of spinal anesthesia induced hypotension in patients undergoing cesarean section. Indones J Anesthesiol Reanim. 2025;7(2):85-92.
Ferrarezi WP, Braga AFA, Ferreira VB, et al. Spinal anesthesia for elective cesarean section. Bupivacaine associated with different doses of fentanyl: randomized clinical trial. Braz J Anesthesiol. 2021;71(6):642-648.
Giaccari LG, Coppolino F, Aurilio C, et al. Is intrathecal bupivacaine plus dexmedetomidine superior to bupivacaine in spinal anesthesia for a cesarean section? A systematic review and meta-analysis. Eur Rev Med Pharmacol Sci. 2024;28(15):4067-4079.
Jacob AR, Paul J, Rajan S, Ravindran GC, Kumar L. Effect of injection speed of heavy bupivacaine in spinal anesthesia on quality of block and hemodynamic changes. Anesth Essays Res. 2021;15(4):348-351.
Kabnani MW, Susanto A, Hikmanti A. Overview of hemodynamic status in patients under spinal anesthesia. J Midwifery Nurs. 2025;7(1):169-175.
Luca E, Schipa C, Cambise C, Sollazzi L, Aceto P. Implication of age-related changes on anesthesia management. Saudi J Anaesth. 2023;17(4):474-481.
Nanmi NP, Lailly H, Armyanti I, Novitarini P, Handoko W. Effect of spinal anesthesia on blood pressure during cesarean section in private Indonesian hospital. Maj Kedokt Bandung. 2025;57(2).
Santoso TB. Perbandingan efektifitas antara penggunaan bupivacaine hiperbarik dengan levobupivacaine isobarik pada pasien sectio caesaria dengan anestesi spinal. J Ris Ilmu Kesehat Keperawatan. 2023;1(1).
Shim JW, Cho YJ, Moon HW, et al. Analgesic efficacy of intrathecal morphine and bupivacaine during the early postoperative period in patients who underwent robotic-assisted laparoscopic prostatectomy: a prospective randomized controlled study. BMC Urol. 2021;21(1).
Suljević I, Šurković I, Turan M, et al. Clinical effects of hyperbaric lidocaine and bupivacaine in spinal anesthesia – our experience. Acta Clin Croat. 2022;61(Suppl 2):22-27.
Tubalawony SL, Siahaya A. Pengaruh anestesi spinal terhadap kejadian hipotermi pada pasien post operasi. J Keperawatan. 2023;15(1):331-338.
Wati H, Sandi DAD. Perbandingan profil farmakokinetika bupivakain 0,5% pada pasien hamil normotensi dan preeklampsia yang menjalani sectio caesarea di RSUP dr. Sardjito Yogyakarta. Indones J Clin Pharm. 2017;6(1):32-37.
Zulkifli M, Salahuddin A, Ahmad MR. Perbandingan efektivitas anestesi spinal menggunakan bupivakain 0,5% hiperbarik dosis 7,5 mg dengan 5 mg pada seksio sesarea.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Catur Nugroho Kuncoro Jati, Marta Tania Gabriel Ching Cing, Endiyono, Rully Annisa (Author)
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
